Mechanisms guiding the slow pace of maturation in human neurons uncovered

Nature, Published online: 28 February 2024; doi:10.1038/d41586-023-04141-9Nerve cells in the human brain take a remarkably long time to mature. This study identifies an epigenetic ‘barrier’ in neural precursor cells that determines the rate of neuronal maturation and is slowly released during the process. Inhibition of the barrier is shown to accelerate maturation in multiple human stem-cell-based models.

  Nature & & science   Feb 28, 2024   0   47  Add to Reading List
Mechanisms guiding the slow pace of maturation in human neurons uncovered

Nature, Published online: 28 February 2024; doi:10.1038/d41586-023-04141-9

Nerve cells in the human brain take a remarkably long time to mature. This study identifies an epigenetic ‘barrier’ in neural precursor cells that determines the rate of neuronal maturation and is slowly released during the process. Inhibition of the barrier is shown to accelerate maturation in multiple human stem-cell-based models.
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