Targeted protein degradation via intramolecular bivalent glues

Nature, Published online: 21 February 2024; doi:10.1038/s41586-024-07089-6Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.

  Nature & & science   Feb 25, 2024   0   52  Add to Reading List
Targeted protein degradation via intramolecular bivalent glues

Nature, Published online: 21 February 2024; doi:10.1038/s41586-024-07089-6

Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.
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