Substrate-induced condensation activates plant TIR domain proteins

Nature, Published online: 13 March 2024; doi:10.1038/s41586-024-07183-9Binding of the substrates NAD+ and ATP to the plant Toll/interleukin-1 receptor (TIR) domain proteins induces phase separation and, thereby, activation of TIR enzymatic and immune signalling activity.

  Nature & & science   Mar 13, 2024   0   38  Add to Reading List
Substrate-induced condensation activates plant TIR domain proteins

Nature, Published online: 13 March 2024; doi:10.1038/s41586-024-07183-9

Binding of the substrates NAD+ and ATP to the plant Toll/interleukin-1 receptor (TIR) domain proteins induces phase separation and, thereby, activation of TIR enzymatic and immune signalling activity.
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