Oxidative cyclization reagents reveal tryptophan cation–π interactions

Nature, Published online: 06 March 2024; doi:10.1038/s41586-024-07140-6Global profiling of hyper-reactive tryptophan sites across whole proteomes using tryptophan chemical ligation by cyclization (Trp-CLiC) reveals a systematic map of tryptophan residues that participate in cation–π interactions, including functional sites that can regulate protein-mediated phase-separation processes.

  Nature & & science   Mar 6, 2024   0   51  Add to Reading List

Nature, Published online: 06 March 2024; doi:10.1038/s41586-024-07140-6

Global profiling of hyper-reactive tryptophan sites across whole proteomes using tryptophan chemical ligation by cyclization (Trp-CLiC) reveals a systematic map of tryptophan residues that participate in cation–π interactions, including functional sites that can regulate protein-mediated phase-separation processes.
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