Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07087-8Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.

  Nature & & science   Feb 28, 2024   0   37  Add to Reading List
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07087-8

Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.
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